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From Berlin-Brandenburg (BER) airport:
Take the RE7 or RE 14 regional train to the Alexanderplatz S-Bahn station, then the U8 in the direction of Wittenau for one station to the Weinmeisterstraße U-Bahn station (journey time approx. 40 minutes / 1-minute walk)
Take the FEX to the main station, the S-Bahn in the direction of Alexanderplatz for two stations to the Hackescher Markt S-Bahn station (journey time approx. 50 minutes / 5-minute walk)
Taxi fare: approximately €40.00
From Berlin-Schönefeld Airport:
Take the S 45 to the Hermannstraße S-Bahn station. Then take the U8 line to the Weinmeisterstraße station. (approximately 50 minutes)
Taxi fare: approximately €30.00
From Berlin central station:
Take the S-Bahn two stations in the direction of Alexanderplatz to Hackescher Markt. (approximately 5 minutes / 5-minute walk)
From the Ostbahnhof railway station:
Take the S-Bahn three stations in the direction of Friedrichstraße and get out at Hackescher Markt. (approximately 5 minutes / 5-minute walk)